Big Dynorphin (Dyn)
DYN is an opioid with various physiological functions. It was first recognized as a significant analgesic function, but it has a strong addiction and drug dependence on the human body. Later, it was found that it has obvious regulating effects on many functions of the body, such as cardiovascular system and respiratory system.
DYN are endogenous opiates that normally play a role in inhibiting chronic pain in the body. Josephine Lai and colleagues studied strong DYN. High levels of DYN are present in patients with chronic pain conditions in parts similar to nerve damage, but unlike other endogenous opiates, they actually exacerbate pain.
The authors explain the troubling phenomenon: strong DYN also activate receptors for bradykinin in the spinal cord, an receptor that can lead to hypersensitivity to pain. A drug that suppresses the receptor for bradykinin protects against neuropathic pain, but only if levels of DYN rise.Mice deprived of the receptor showed no increased pain after exposure to the potent DYN.
The findings suggest that the effects of new opiates on bradykinin and opiate receptors should be carefully evaluated before applying them to pain treatment.The new findings may help develop a new drug for treating chronic pain.
At present, DLDEVELOP co. LTD has developed corresponding DYN Elisa products. To get more information, you could contact our professional staff directly or directly to our website:
http://www.dldevelop.com/Research-reagent/dl-dyn-hu.html
http://www.dldevelop.com/Research-reagent/dl-dyn-mu.html
http://www.dldevelop.com/Research-reagent/dl-dyn-ra.html
DYN are endogenous opiates that normally play a role in inhibiting chronic pain in the body. Josephine Lai and colleagues studied strong DYN. High levels of DYN are present in patients with chronic pain conditions in parts similar to nerve damage, but unlike other endogenous opiates, they actually exacerbate pain.
The authors explain the troubling phenomenon: strong DYN also activate receptors for bradykinin in the spinal cord, an receptor that can lead to hypersensitivity to pain. A drug that suppresses the receptor for bradykinin protects against neuropathic pain, but only if levels of DYN rise.Mice deprived of the receptor showed no increased pain after exposure to the potent DYN.
The findings suggest that the effects of new opiates on bradykinin and opiate receptors should be carefully evaluated before applying them to pain treatment.The new findings may help develop a new drug for treating chronic pain.
At present, DLDEVELOP co. LTD has developed corresponding DYN Elisa products. To get more information, you could contact our professional staff directly or directly to our website:
http://www.dldevelop.com/Research-reagent/dl-dyn-hu.html
http://www.dldevelop.com/Research-reagent/dl-dyn-mu.html
http://www.dldevelop.com/Research-reagent/dl-dyn-ra.html
