Human Fibronectin (FN)
Recently, from the Rockefeller university scientists have discovered that a protein called FN viscous or can promote breast cancer cells in the activity of estrogen, related research published in international Journal of Cell Biology, the article, the researchers illustrate a FN (fibronectin) regulation of estrogen receptor signal by the new mechanism, the researchers suggest that exposure to FN or can prolong the activity of estrogen receptors in breast cancer cells.
Estrogen in healthy cells and cancer cells plays a key role on the function, it can adsorption to the estrogen receptors on the surface of cells, and promote the cell growth and survival, but too much can cause the rapid cell proliferation or estrogen receptor activity, lead to the growth of tumor, about 75% of all breast cancer is considered to be estrogen receptor-positive breast cancer, because estrogen promotes breast cancer progress unceasingly.
As cancer cells began to invade surrounding tissues, it will run into a sticky FN, researchers Sampayo explains, in normal breast tissue, epithelial cells will not contact with FN, FN is part of the extracellular matrix, and the extracellular matrix to proteins and cells surrounding the molecules of a special kind of wire mesh screen; In tumor tissues, peripheral network production is not normally regulated. Previous studies have shown that high levels of FN and its receptor, visa1 - integrin, are directly associated with lower breast cancer survival, but the molecular mechanisms involved are unclear. In this study, the researchers found, FN can enhance the activity of estrogen receptors in breast cancer cells, when breast cancer cells surrounded by FN, estrogen receptor will avoid damaged by cellular garbage processor - lysosome, which will drive the carcinoma cells growth and reproduction, in addition it will also promote breast cancer cells to estrogen receptors targeting the function of common endocrine drug therapy have tolerated.
Finally, the researchers said, and by means of intervention therapy of FN may be able to influence the activity of estrogen receptors in breast cancer cells, it may could help treatment for drug resistance of breast cancer patients, in addition, this paper study, the researchers also clarified the tumor cell protein molecules around the network influence the molecular mechanisms of cancer progression.
At present, DLDEVELOP co. LTD has developed corresponding FN Elisa products. To get more information, you could contact our professional staff directly or directly to our website:
http://www.dldevelop.com/Research-reagent/dl-fn-hu.html
http://www.dldevelop.com/Research-reagent/dl-fn-mu.html
http://www.dldevelop.com/Research-reagent/dl-fn-ra.html
Estrogen in healthy cells and cancer cells plays a key role on the function, it can adsorption to the estrogen receptors on the surface of cells, and promote the cell growth and survival, but too much can cause the rapid cell proliferation or estrogen receptor activity, lead to the growth of tumor, about 75% of all breast cancer is considered to be estrogen receptor-positive breast cancer, because estrogen promotes breast cancer progress unceasingly.
As cancer cells began to invade surrounding tissues, it will run into a sticky FN, researchers Sampayo explains, in normal breast tissue, epithelial cells will not contact with FN, FN is part of the extracellular matrix, and the extracellular matrix to proteins and cells surrounding the molecules of a special kind of wire mesh screen; In tumor tissues, peripheral network production is not normally regulated. Previous studies have shown that high levels of FN and its receptor, visa1 - integrin, are directly associated with lower breast cancer survival, but the molecular mechanisms involved are unclear. In this study, the researchers found, FN can enhance the activity of estrogen receptors in breast cancer cells, when breast cancer cells surrounded by FN, estrogen receptor will avoid damaged by cellular garbage processor - lysosome, which will drive the carcinoma cells growth and reproduction, in addition it will also promote breast cancer cells to estrogen receptors targeting the function of common endocrine drug therapy have tolerated.
Finally, the researchers said, and by means of intervention therapy of FN may be able to influence the activity of estrogen receptors in breast cancer cells, it may could help treatment for drug resistance of breast cancer patients, in addition, this paper study, the researchers also clarified the tumor cell protein molecules around the network influence the molecular mechanisms of cancer progression.
At present, DLDEVELOP co. LTD has developed corresponding FN Elisa products. To get more information, you could contact our professional staff directly or directly to our website:
http://www.dldevelop.com/Research-reagent/dl-fn-hu.html
http://www.dldevelop.com/Research-reagent/dl-fn-mu.html
http://www.dldevelop.com/Research-reagent/dl-fn-ra.html
