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A Variant of the BDNF Gene Causes Anxiety

Brain-derived neurotrophic factor (BDNF) is a protein that can regulate the development of neurons. It is mainly found in the brain, but also in other areas of the body, and is most concentrated in the cortex and hippocampus. , Hippocampus and other parts, Changes in brain-derived neurotrophic factor levels are related to neurological diseases, mental illnesses and cognitive developmental delay.
Researchers found that a common single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene produced similar phenotypes in mice and humans, and the BDNF gene was associated with anxiety-related behaviors. A knockout strain of inbred mice expressing a variant of BDNF reproduced the phenotypic effects of human polymorphism. Both are impaired in eliminating the conditioned fear response, which is parallel to human atypical frontal amygdala activity.
Researchers use functional magnetic resonance imaging (fMRI) to scan the human brain in order to distinguish the difference in brain function between people with normal or abnormal neurotrophic factors. They found that in people with abnormal brain-derived neurotrophic factors, the brain's circuit in the frontal cortex and amygdala involved in signal safety has changed, while people with normal brain-derived neurotrophic factors did not have such changes.
Thus, this variant of the BDNF allele may play a role in causing anxiety symptoms, showing a learning disability in the brain for safety and threat signals, and the effectiveness of treatment that relies on regression mechanisms such as exposure therapy. The findings could help scientists develop new clinical drugs to treat anxiety disorders such as phobias and post-traumatic stress disorder in humans. At present, Wuxi Donglin Sci & Tech Development Co.,Ltd. has developed a variety of ELISA products to test the level of BDNF. . For more information, you can directly contact our professionals or visit our website:

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