Glucagon
In the early 1820s, glucagon was first identified and renamed. It was purified and determined in the 1850s. In the 1870s, it was determined to play a most fundamental role in the pathophysiology of diabetes. More attention was paid to insulin hypoglycemic. Effect. Insulin has been used to treat patients with type 1 diabetes for nearly a century. There is no doubt that insulin has saved many lives, but it cannot completely control the occurrence of hypoglycemia and reduce the risk of complications. Therefore, on the way to understand the pathophysiology of diabetes, the researchers found isletα cells that secrete glucagon.
The level of glucagon in blood circulation is very low, about 10pmol/L (35pg/mL), the physiological concentration range from hypoglycemia to hyperglycemia is 0-30 pmol/L (0-105pg/mL), and the half-life in human body is 7 min, the half-life in rats and dogs is 2 min and 5 min respectively. The glucagon receptor is a seven-fold transmembrane g-coupled protein receptor, which is mainly expressed in the liver. When studying glucagon receptors in rats, it was found to be expressed in the stomach, lungs, adrenal glands, small intestine, brain, heart, spleen and brown and white fat.
The factors affecting glucagon secretion are mainly divided into three aspects: First, plasma concentration and other hormones; Second, beta cells (insulin, Zn2+, aminobutyric acid), delta cells (somatostatin); Third, neuromodulation. In healthy humans, when the blood glucose concentration is elevated, the bypass β cells in the islets inhibit the secretion of glucagon from the α cells by the secretion of insulin. Glucagon secretion is complex, including the brain, autonomic nervous system, small intestine, and autocrine signals. Other studies have shown that leptin secreted by adipocytes has an inhibitory effect on glucagon.
With the advancement of pharmaceutical research and development, our DLdevelop is also working hard for this. We focuse on the research and development of Elisa reagents, and has achieved good results. Regarding the Glucagon mentioned above, DLdevelop has developed some related kits, such as DL-GCG-Hu, DL-GCG-Mu. If you want to know more about it, you could contact our professional staff directly or directly to our website:
https://dldevelop.com/Research-reagent/dl-gc-hu.html
https://dldevelop.com/Research-reagent/dl-gcg-mu.html
The level of glucagon in blood circulation is very low, about 10pmol/L (35pg/mL), the physiological concentration range from hypoglycemia to hyperglycemia is 0-30 pmol/L (0-105pg/mL), and the half-life in human body is 7 min, the half-life in rats and dogs is 2 min and 5 min respectively. The glucagon receptor is a seven-fold transmembrane g-coupled protein receptor, which is mainly expressed in the liver. When studying glucagon receptors in rats, it was found to be expressed in the stomach, lungs, adrenal glands, small intestine, brain, heart, spleen and brown and white fat.
The factors affecting glucagon secretion are mainly divided into three aspects: First, plasma concentration and other hormones; Second, beta cells (insulin, Zn2+, aminobutyric acid), delta cells (somatostatin); Third, neuromodulation. In healthy humans, when the blood glucose concentration is elevated, the bypass β cells in the islets inhibit the secretion of glucagon from the α cells by the secretion of insulin. Glucagon secretion is complex, including the brain, autonomic nervous system, small intestine, and autocrine signals. Other studies have shown that leptin secreted by adipocytes has an inhibitory effect on glucagon.
With the advancement of pharmaceutical research and development, our DLdevelop is also working hard for this. We focuse on the research and development of Elisa reagents, and has achieved good results. Regarding the Glucagon mentioned above, DLdevelop has developed some related kits, such as DL-GCG-Hu, DL-GCG-Mu. If you want to know more about it, you could contact our professional staff directly or directly to our website:
https://dldevelop.com/Research-reagent/dl-gc-hu.html
https://dldevelop.com/Research-reagent/dl-gcg-mu.html
