SP-A Can Protect Lung Epidermis From HBD3
Since it was found that epithelial cells pre cultured in SP-A were not subject to the cytotoxicity of hBD3, the direct interaction between SP-A and hBD3 may make SP-A an important factor to reduce the toxicity of hBD3. Consistent with the in vitro analysis, compared with the effect on WT mice, after intratracheal administration of hBD3 to SP-A -/- mice, more severe tissue damage will occur to the lung epidermis. These data indicate that SP-A protects the lung epithelium from tissue damage caused by hBD3.
In addition, the study found that the functional region of SP-A lies in Tyr161-Lys201. At present, this area has been artificially synthesized and is temporarily called SP-A Y161-G200. Subsequent experiments showed that it could also inhibit the cytotoxicity of hBD3. Therefore, SP-A Y161-G200 is likely to become a therapeutic drug to protect tissues during inflammation.
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