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Home > FC Antibody

Anti-Mouse CD22 Monoclonal Antibody(PE/Cyanine7 Conjugated)

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Product name: Anti-Mouse CD22 Monoclonal Antibody(PE/Cyanine7 Conjugated)
Catalog:

DL20369F

Synonyms : B-cell receptor CD22,Cd22,B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,Siglec-2,T-cell surface antigen Leu-14,CD22,Lyb-8, Siglec2
Reactivity: Mouse
Applications: FCM
Size: 20 Tests/50 Tests/100 Tests/200 Tests
Host: Mouse
Clonality:
Conjugation:
Background:

The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig ?? chain are augmented in the presence of Cy34.1 mAb.

Concentration:
Buffer: PBS with 0.05% Proclin300, 1% BSA
Gene_ID: 12483
Clone_NO: Cy34.1
SwissProt: P35329
Isotype: Mouse IgG1, ?
Storage: Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.

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