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Home > FC Antibody

Anti-Human Notch3 Monoclonal Antibody(APC Conjugated)

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Product name: Anti-Human Notch3 Monoclonal Antibody(APC Conjugated)
Catalog:

DL21927F

Synonyms : NOTCH3,Notch 3,Notch 3 extracellular truncation,Notch 3 intracellular domain
Reactivity: Human
Applications: FCM
Size: 20 Tests/50 Tests/100 Tests/200 Tests
Host: Mouse
Clonality:
Conjugation:
Background:

The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome.

Concentration:
Buffer: PBS with 0.05% Proclin300, 1% BSA
Gene_ID: 4854
Clone_NO: MHN3-21
SwissProt: Q9UM47
Isotype: Mouse IgG1, ?
Storage: Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.

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