Anti-Human FOXP3 Monoclonal Antibody(Biotin Conjugated)
|Product name:||Anti-Human FOXP3 Monoclonal Antibody(Biotin Conjugated)|
|Synonyms :||Forkhead box protein P3,FOXP3,Scurfin,Forkhead box protein P3 41 kDa form,IPEX|
|Size:||25 ug/100 ug|
FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 ??2) lacking exon 2.
|Buffer:||PBS with 0.05% Proclin300, 1% BSA|
|Isotype:||Mouse IgG1, ?|
|Storage:||Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.|
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