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FAQ
Purified Anti-Human CD49d Monoclonal Antibody
| Product name: | Purified Anti-Human CD49d Monoclonal Antibody | |
| Catalog: | DL20592F |
|
| Synonyms : | Integrin alpha-4,ITGA4,CD49 antigen-like family member D,Integrin alpha-IV,VLA-4 subunit alpha,CD49d | |
| Reactivity: | Human | |
| Applications: | FCM,IHC,IP | |
| Size: | 25 ug/100 ug | |
| Host: | Mouse | |
| Clonality: | ||
| Conjugation: | ||
| Background: | CD49d is a 150 kD ?? integrin chain known as ??4 integrin or VLA-4 ?? chain. It forms a heterodimer with either integrin ??1 (??4??1, VLA-4) or ??7 (??4??7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. ??4??7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells. |
|
| Concentration: | 0.2 mg/mL | |
| Buffer: | PBS with 0.05% Proclin300 | |
| Gene_ID: | 3676 | |
| Clone_NO: | BU49 | |
| SwissProt: | P13612 | |
| Isotype: | Mouse IgG1, ? | |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. | |
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